And I have read enough to have a myopic view of what they know and what occurs within a cell at a biochemical and physiological level. They factor for clinical medicine is that hormones are what control th eentire process. The problem for obesity and diabetes is that we focus on insulin which is not the major issue. It is distal to the real problem. Leptin. This story is very similar to what has been happening in heart disease research for 50 yrs. We believe it caused by cholesterol and fats in medicine when the real target is carbohydrates and omega 6 FFA. The low carb community needs to realize if it were all about insulin only we should have slayed the dragon with treating insulin resitance. Well medicine does that now. How is that working out for Diabetics? They are dying at record numbers and the recent ACCORD data says they die on avg 6 yrs earlier with IDEAL treatment. That tells you something is amiss. We are aiming at the wrong target. My blog is about optimizing all life and disease by tying it all together. As I lay it out you will begin to see how it is all tied together.
Dr Kruse, I have already replied to your blog, and I don't mean to go on at you, but I will add a couple of comments here.
I question some of the things you write, but I do admire what you are trying to do, so if I come over as critical, please try not to take it too badly. I am trying (as a non-scientist, although worked in a scientific background all my working life) to be scientifically honest, and not just accepting propositions at face value, but testing and challenging them. This is part of the scientific method, as I'm sure you would accept.
Slain the dragon of insulin resistance? Of course medicine hasn't done that, and Gary Taubes already told us why, and what we need to do about it. That doesn't mean that insulin is not the problem.
"We are aiming at the wrong target" - And you are now certain that leptin resistance is the right target. So how's that going? Did injecting obese people with leptin make them normal? No, not as far as I know. Now that doesn't necessarily prove it's not leptin that's the issue, but it does make one stop to think about it.
If you care to go over to Stephan Guyenet's blog, you will find a (rather vociferous) commenter there who says that leptin didn't make her lose excessive weight - she did that by low-carbing. But then she found problems in keeping the weight off, and found that leptin injections then seemed to help her keep the weight off and not be hungry, cold and tired all the time.
She has a hypothesis as to why: An ex-obese person slimmed down to BMI=22 is not the same as a never-obese person BMI=22: She has a lot more fat cells, only they are now shrunken, and not producing enough leptin for her body mass. The only way she could produce enough leptin to be in balance and not be hungry would be for the fat cells to grow again, i.e. to get fat again. (Curiously, Gary says something similar in GC, BC without mentioning leptin). It's an interesting story and theory. Her "handle" is (IIRC) "It's the woo2". She doesn't believe leptin resistance was her problem. If that was the case, her leptin injections wouldn't be working (and they are very low dose)· Leptin is playing a part, but it may not be the key part, as you believe. Admittedly, by her own admission, she has had a difficult hormonal history, and may not be representative of the average obese person. On the other hand, she probably has more practical experience of leptin than most of us here.