Hi Ted, thanks for your in depth reply! :-) I am on Dr Davis forum and am a patient of his. I have not seen him since discovering the ApoE 4/4 news. It is a state away and I will see him when the weather breaks and roads are drivable.
There is a lot of stipulation over at TYP about what diet and supplements are best for ApoE4/4. The one other person on TYP forum who has the doulbe 4 alelle is also a patient of Dr Davis and she is on a low calorie, low fat, low carb program and has a BMI of 18! Dr Davis says no coconut oil and no egg yolks at all for 4/4's and as little SF as humanly possilbe! I am just having a hard time swallowing this advise. Seems counter intuitive to me. TYP is going to have an 'official' stance regarding Apoe 4 within a few weeks. I am working on getting up my levels of vitamin D, apparently this is also a problem with this polymorphism and fat soluble nutrients. I run a fine line between overloading my kidneys and getting my D levels up. I have struggled to get into the high thirties over the past 2 years. My RBC magnesium levels were also moderatley low according to Dr Davis' scale, so I am not mega supplementing with glycinate, malate and citrate forms. As for the omega 3 status, I just had a test for that and will get results back soon, but again Dr Davis and Dr Goldstrich have cautioned me that only 500mg per day of omega 3 from fish oil for 4's. I take several forms of probiotics and prebiotics....plus eat fiber for gut flora.
Since seeing Dr Davis and joining TYP forum last September, I've been directed to decrease SF and eat unlimited amounts of veggies and nuts, avocados, seeds etc... Reduce protein, add more fats. To my already HUGE supplement list, Dr Davis added: 1,000mg niacin, K2 1,000, iodine 1,000mcg, was instructed to take 3,600mg of EPA/DHA until the discovery of 4/4, now on 500mg of DHA and one cap of krill. My vitamin D was upped to 8,000 in September, bood draw in November show a decrease in D levels. Upped to 12,000 in November and January showed only 39, now on 20,000 IU's of D. I had one bout of kidney stress so far, but was also experiencing the flu and may have been dehydrated.
All of this seems counterintuitive to me after having followed low omega 6, high omega 3, low carb (ketogenic), peleo/atkins...higher SF. The lipid profile posted above was before starting TYP, so you can see my fomer Paleo way of eating wasn't doing much good for the lipids. I am schedulled to get an NMR this month. It will be interesting to see what changes have been made in lipids. I am at least hoping for an increase in HDL.