Caffeine and free fatty acids
Caffeine and free fatty acids , 06-14-2008 12:23 PM


Advanced Low-Carber


I just found this interesting article saying that caffeine increases availability of free fatty acids for fuel. Has anyone else ever heard this? I've copied the explanation and link to the web page below.

"Our bodies store chemical energy that cannot immediately be used in the form of fat, and store the fat in specialized fat cells. When the body needs to use those engergy reseves, it signals the fat cells to undergo a process called lipolysis, which converts fat into fatty-acids and glycerol. The fatty-acids are then used for energy. The body signals this using chemical messengers in the blood (aka hormones), which bind to a receptors on the cell surface. When the receptors recognize a hormone, they send another chemical signal into the interior of the cell that tells the cell to undergo lipolysis. This signal is a molecule called cyclic Adenosine Monophosphate or cAMP. Once the signal has been sent into the cell, special enzymes in the cell deactivate the cAMP. The signal can be re-sent if more hormone binds to the receptor, but if there is no more hormone present then the cAMP signal will only last as long as it takes the enzymes to deactivate it. Once the cAMP signal stops, lipolysis will stop.

Caffeine is a molecule that looks alot like Adenine, which is an important part of the cAMP molecule. The chemical name of Caffeine is Trimethylxanthine, meaning that it is a Xanthine molecule with three methyl groups attached. Xanthine is a precursor of Adenine. When Caffeine is present in a fat cell, it interferes with the enzymes that deactivate cAMP ( possibly because it looks like a funny Adenosine molecule), slowing them down. As a result, the cAMP signal lasts longer in the cell, and lipolysis contines for a longer time. So in essense, Caffeine tricks your your fat cells into releasing more fatty-acids than needed by making the hormone signal last longer."

http://www.madsci.org/posts/archives/199....Bc.r.html
RE: Caffeine and free fatty acids , 06-14-2008 12:59 PM


Advanced Low-Carber


Lauren,
Thanks for posting that. I'm enjoying my big mug of morning coffee right now. My husband has a small roaster and he roasts up a fresh batch every three days or so. It is so yummy. Of course we put in a couple of tablespoons of heavy cream. I'd read in other places that coffee is good for the liver, I tell myself that every morning when I'm tempted to skip it to follow in Charles footsteps. You've provided another excuse to keep sipping my joe.

Mel
RE: Caffeine and free fatty acids , 06-14-2008 06:57 PM


Advanced Low-Carber


Cool post Lauren, thanks!

Mel my Denny would love you and your DH! He loves freshly roasted beans! (Me, I'm a philistine. I love the Folger's decaf :blush: )
RE: Caffeine and free fatty acids , 06-16-2008 09:36 AM


Advanced Low-Carber


I am still in love with my coffee...coffee...coffee...coffee...coffee

Or maybe i'm in love with the fuel liberated by the Caffeine or cAMP or what ever.......coffee...coffee...coffee...coffee...coffee...

Maybe i've had too much already...happy monday
travis

avatar was in chicago in august 08
RE: Caffeine and free fatty acids , 06-16-2008 11:23 AM


Advanced Low-Carber


I'm looking forward to Wednesday morning. That's when I will have completed two weeks without coffee, and I can close the book on that particular experiment.

I have not experienced any magical coffee-free weight loss. Nor a hitherto-unknown wellspring of robust energy. Nor a sense of liberation from a supposed addiction. Just a sense of deprivation as I try to ignore the rich, seductive aroma of my husband's fresh-ground, fair-trade, shade-grown brew.

I like what I like. So sue me.

Do you know what's in your mayonnaise? You do if you make your own:
http://vesnavuynovich.blogspot.com/2008/...ecipe.html

Low-carb in earnest since March 2007
Low-carb believer since September 2001 (on and off practice)
RE: Caffeine and free fatty acids , 06-16-2008 01:28 PM


Moderator


I've never noticed that coffee has any affect on my weight one way or another either. What bothered me about drinking coffee with caffeine was the fact that I was addicted to it. I hated that I HAD to have it every day or I would get a headache. Maybe it wouldn't have bugged me so much if I was getting the "buzz" that most people get from caffeine but I wasn't. It made me very sleepy and a couple cups of it would make me feel like going back to bed. I'm a morning person and usually have a lot of energy when I get up so I don't need anything to perk me up anyway. Since I do like the taste of coffee now and then, I drink decaf so that I won't risk getting hooked again.

My sites:
Linda's Low Carb Menus & Recipes
In the Kitchen with Linda Blog
RE: Caffeine and free fatty acids , 06-18-2008 08:50 PM


Junior Low-Carber


The deal with caffeine is that it crashes your blood sugar. Try this experiment.

Some mornings - get up and drink caffenated coffee or soft drink - don't eat breakfast and see how long it takes to get really hungry.

Other mornings - get up and drink water or decaff - don't eat breakfast and see how long it takes to get really hungry.

For most people drinking cafeine makes them very hungry in about an hour.

So what you want to do is drink caffeine with your low carb meals - then you get the benefit of caffeine - but your blood sugar does not crash.

for a dose of reality and common sense, try
http://www.KeithConnectsTheDots.com
RE: Caffeine and free fatty acids , 06-18-2008 10:11 PM


Senior Low-Carber


Hmmm, caffeine on its own was always a great appetite suppressant for me, for hours.

My concern with caffeine is doesn't it increase insulin?
RE: Caffeine and free fatty acids , 06-19-2008 08:46 AM


Advanced Low-Carber


Wendyoh
About caffeine(makes me happy), from what i have read it looks like the oils in the coffee are what is responsible for increasing the levels of low density lipoproteins in the blood. Also a metabolite of caffeine is called paraxanthine and it is responsible for the lipolytic properties of caffeine. Lipolysis = Fuel = Happy..Happy...Happy
As to your question about caffeine and insulin i have read a journal artice from Belgium that reports regular coffee administration increases non esterified fatty acids without modifying plasma glucose, insulin, cortisol, or growth hormone concentrations. Coffee makes me happy.
What i do is to brew my coffee with a paper filter which absorbs some of the oils and it also traps the small sediment particles from the fine grind that i use.
You are right that coffee is a great appetite suppressant and i think that it is the release of fat into circulation that does it.
Oh and did i mention that coffee makes me happy.
travis

avatar was in chicago in august 08
RE: Caffeine and free fatty acids , 06-19-2008 08:53 AM


Junior Low-Carber


Wendyoh Wrote:Hmmm, caffeine on its own was always a great appetite suppressant for me, for hours.

My concern with caffeine is doesn't it increase insulin?

Do you have insulin resistance or insulin or blood sugar problems?

Insulin is usually increased in response to excess carbohydrates (which cause rise in blood sugar).

Caffeine usually decreases insulin (in obese people) - which makes you hungry.

for a dose of reality and common sense, try
http://www.KeithConnectsTheDots.com
RE: Caffeine and free fatty acids , 06-19-2008 09:16 AM


Senior Low-Carber


travis t Wrote:Wendyoh
About caffeine(makes me happy), from what i have read it looks like the oils in the coffee are what is responsible for increasing the levels of low density lipoproteins in the blood. Also a metabolite of caffeine is called paraxanthine and it is responsible for the lipolytic properties of caffeine. Lipolysis = Fuel = Happy..Happy...Happy
As to your question about caffeine and insulin i have read a journal artice from Belgium that reports regular coffee administration increases non esterified fatty acids without modifying plasma glucose, insulin, cortisol, or growth hormone concentrations. Coffee makes me happy.
What i do is to brew my coffee with a paper filter which absorbs some of the oils and it also traps the small sediment particles from the fine grind that i use.
You are right that coffee is a great appetite suppressant and i think that it is the release of fat into circulation that does it.
Oh and did i mention that coffee makes me happy.
travis

Are you saying you like caffeine?

Do you have a link to that journal article? I'm very interested in its findings, especially on cortisol.

I don't actually like coffee. I love the smell. Hate the taste. When "using" caffeine, I buy caffeine pills, and split them up b/c 200 mg at once makes me too happy
RE: Caffeine and free fatty acids , 06-19-2008 09:19 AM


Senior Low-Carber


kebaldwin Wrote:Do you have insulin resistance or insulin or blood sugar problems?

Insulin is usually increased in response to excess carbohydrates (which cause rise in blood sugar).

Caffeine usually decreases insulin (in obese people) - which makes you hungry.

My blood sugar does rise too much after carbohydrate meals. If I keep my carbs low, my blood sugar is great.

Are you saying that caffeine only decreases insulin in obese people, and not in those leaner? I have never read about this. Everything I've seen suggests that caffeine increases insulin, which can contribute to insulin resistance. I guess I'm just confused Can you tell me where you learned this?
RE: Caffeine and free fatty acids , 06-19-2008 09:54 AM


Junior Low-Carber


Wendyoh Wrote:Are you saying that caffeine only decreases insulin in obese people, and not in those leaner? I have never read about this. Everything I've seen suggests that caffeine increases insulin, which can contribute to insulin resistance. I guess I'm just confused Can you tell me where you learned this?

1. We are all different - so we won't all get exactly the same response. For example - for some people - stimulants can make them sleepy - the opposite of what you expect.

2. Caffeine is one of the most argued about things. It does have different effects on different people. I would think that the amount of caffeine, wether you take it on an empty stomach or full stomach, the magnitude of your blood sugar problems, etc will change the results.

BTW - I don't drink coffee - I drink diet sodas. So perhaps caffeinated coffee is different from caffeinated diet soda.

3. I assume that obese people are much more likely to have blood sugar, insulin, and cortisol problems than people of normal weight. I would expect different supplements/drugs to effect obese and normal weight people differently. Things effect me differently after 5 years of low carbing. For example, I am starting to find that chromium hurts me more now (bad headaches when do hard work in the heat) than helps me control cravings and hunger. Whereas when I first started LCing - it was a neccessity. I also started taking 800 mcg per day.

4. Where did I learn things? Everywhere. I have read numerous books (LCing, hormones, omega 3s, nutrition, etc), read most Atkins books and watched his vidoes, experimented on myself, and talked with a lot of others on low carb diets. There is a lot of information out there that is wrong - in fact - completely backwards. I tend to listen more to the people that have been there and done that (i.e. been obese and lost the weight via low carbing) than some "health expert" that has never been obese and lost weight via low carbing. Those are the people that usually have it completely backwards.

Taking all of this into consideration - is why I suggested everyone try the caffeine experiment. It should tell you how caffeine will effect your blood sugar and insulin levels.

for a dose of reality and common sense, try
http://www.KeithConnectsTheDots.com
RE: Caffeine and free fatty acids , 06-19-2008 10:13 AM


Advanced Low-Carber


Wendyoh
When i first started to drink coffee it was the same with me as i loved the smell of the grounds and also the aroma while it was brewing but could not drink it without wanting to gag. I know that this will sound bad but what i did was to brew it and then let it get cool enough to just chug it. Over the course of about three months i would drink it warmer and warmer until i loved it hot.

I only cold get to the summary as the full entry requires a subscription.

Jean-Claude Daubresse1, Alfred Luyckx1, Emilie Demey-Ponsart1, Paul Franchimont1 and Pierre Lef

avatar was in chicago in august 08
RE: Caffeine and free fatty acids , 06-19-2008 12:07 PM


Junior Low-Carber


This is all very interesting. I drink coffee during the week to wake up, but on the weekends I don't miss it. I tried skipping it one day this week, and I was slower to wake than normal, but I tried hot tea (no caffeine) and it satisfied any ritual residue I might've had. I don't know how well I could adjust without coffee when things get really hectic and I've got long hours ahead. My big vice is diet soda. I'd rather have a diet soda for breakfast than that cup of coffee, but I resist it.

I've also heard reports back and forth about the good of caffeine, and the bad of caffeine. I would really like to understand what its true nature regarding weight and insulin is once and for all.
RE: Caffeine and free fatty acids , 06-19-2008 12:42 PM


Advanced Low-Carber


I have heard good and bad stuff about caffeine and coffee also, but as i am about to hit forty this summer sometimes i think we should as the evil empire of nike says "JUST DO IT". I mean by that i am the kind of person who could analyze just about anything to complete death. I have done this with diet, macro nutrient ratios, exercise routines, antioxidants, and the list could go on a while. Sometimes i think that this is self defense move because if i wait long enough i won't have to do anything at all. But i can say one thing over the last two weeks this meat, butter, and coffee diet is making me feel like i'm twenty two again. So i have decided to just do it. (and yes there have been a few carb items in there along the way)
travis

avatar was in chicago in august 08
RE: Caffeine and free fatty acids , 06-19-2008 12:56 PM


Junior Low-Carber


travis t Wrote:But i can say one thing over the last two weeks this meat, butter, and coffee diet is making me feel like i'm twenty two again. So i have decided to just do it. (and yes there have been a few carb items in there along the way)

Travis, I'm already 40 and feeling better too (and confess to a few carbs along the way also!). I might not feel 20 again, but I have a clearer head, my skin has cleared up amazingly, and I've lost a little weight while eating more calories than ever, and doing little in the way of exercise. The coffee/caffeine is a minor concern for me at the moment, but I can't help follow the continuing debate about caffeine.

You know it used to be oat bran was the big thing, then not so much. Right now (in popular diet culture) it seems to be whole grains, flax and olive oil, along with the low-fat routine. But in 6 or 7 years, what will they say is good for us? Sunbathing and cigarettes?
RE: Caffeine and free fatty acids , 06-19-2008 02:51 PM


Advanced Low-Carber


Clabbergirl
I still do love to learn and think about new things, but i am trying to not let it get in the way as sometimes it has in the past.
travis

avatar was in chicago in august 08
RE: Caffeine and free fatty acids , 06-19-2008 03:21 PM


Unregistered

 
This is pretty fascinating. I've never looked into it for myself because I never drank coffee. Dr. Atkins was against it but he cited a study that has to do with lowering blood sugar levels and this would seem to support what Lauren posted.

If that's the case, then coffee would seem to act just as adrenaline and mobilize fatty acids. Insulin has the power to override all hormones so if coffee doesn't help you lose weight, hyperinsulinemia is definitely the culprit.

It seems to work a lot like smoking, because nicotine is actually the best fatty acid moblizer out there. Too bad for the side effect on your lungs, but that's just another one of those things. If you eliminate carbohydrates, you can probably enjoy both caffeine and/or smoking without too many adverse effects as some seem to do!

I wonder though, if you don't have carbohydrates in your diet, is caffeine still so addictive?
RE: Caffeine and free fatty acids , 06-19-2008 03:22 PM


Advanced Low-Carber


Clabbergirl
Sunbating and cigarettes? Maybe not to far off, vitamin d from sunbathing and nicotine from cigarettes(by the way it raises dhea and also some think growth hormone) Major league ball players chew for a reason, they think that it helps their visual accuity(you better be able to see well if your hope to hit a 95 mph fastball) Fun stuff for today.
travis

avatar was in chicago in august 08