10-15-2008, 08:06 PM
Interesting study from the journal GASTROENTEROLOGY 2007;133:1423–1429
Elevated Serum Concentrations of Insulin and Glucose Increase Risk of Recurrent Colorectal Adenomas
ANDREW FLOOD,et al
"Subjects in the intervention group were given dietary targets aimed at achieving a low-fat (20% of energy), high-fiber (18 g/1000 kcal of energy intake), and high fruit and vegetable (5–8 servings/day) diet.
Compared with usual diet, the dietary intervention had no effect on adenoma recurrence in the Polyp Prevention Trial."
No surprise there. This is just what we've come to expect from trials like the Women's Health Initiative. Here's where it gets interesting:
"Investigators observed an increased risk whether the measure of exposure was fasting glucose, post-load glucose, or glycosylated hemoglobin, and the 2 studies that considered adenoma as an outcome15,21 also found increased risk with increased glycosylated hemoglobin (RR for both, 1.4–1.5)."
and
"Nonetheless, the highest quartiles for both insulin and glucose were associated with an approximately 50% increased risk of adenoma, and high concentration of glucose was associated with more than a 2.4 times increased odds of advanced adenoma recurrence in multivariable-adjusted modes. In summary, our results showed a greater risk of adenoma recurrence with increased insulin and especially glucose concentrations at baseline. That increased concentrations of insulin and glucose at baseline were associated with subsequent risk for adenoma recurrence, and in particular that increased glucose concentration was associated with a relative risk of more than 2.4 for recurrence for advanced adenoma, has potentially important clinical implications with respect to maintenance of glycemic control in patients with colorectal neoplasia.
15. Platz EA, Hankinson SE, Rifai N, et al. Glycosylated hemoglobin and risk of colorectal cancer and adenoma (United States). Cancer Causes Control 1999;10:379–386.
21. Wei EK, Ma J, Pollak MN, et al. C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev 2006;15:750–755."
So to avoid colorectal cancer, eat the diet that best controls your glycosylated hemoglobin. Anybody have Hemoglobin A1c (HbA1c) results to share, before and after your low-carb adventure?
Elevated Serum Concentrations of Insulin and Glucose Increase Risk of Recurrent Colorectal Adenomas
ANDREW FLOOD,et al
"Subjects in the intervention group were given dietary targets aimed at achieving a low-fat (20% of energy), high-fiber (18 g/1000 kcal of energy intake), and high fruit and vegetable (5–8 servings/day) diet.
Compared with usual diet, the dietary intervention had no effect on adenoma recurrence in the Polyp Prevention Trial."
No surprise there. This is just what we've come to expect from trials like the Women's Health Initiative. Here's where it gets interesting:
"Investigators observed an increased risk whether the measure of exposure was fasting glucose, post-load glucose, or glycosylated hemoglobin, and the 2 studies that considered adenoma as an outcome15,21 also found increased risk with increased glycosylated hemoglobin (RR for both, 1.4–1.5)."
and
"Nonetheless, the highest quartiles for both insulin and glucose were associated with an approximately 50% increased risk of adenoma, and high concentration of glucose was associated with more than a 2.4 times increased odds of advanced adenoma recurrence in multivariable-adjusted modes. In summary, our results showed a greater risk of adenoma recurrence with increased insulin and especially glucose concentrations at baseline. That increased concentrations of insulin and glucose at baseline were associated with subsequent risk for adenoma recurrence, and in particular that increased glucose concentration was associated with a relative risk of more than 2.4 for recurrence for advanced adenoma, has potentially important clinical implications with respect to maintenance of glycemic control in patients with colorectal neoplasia.
15. Platz EA, Hankinson SE, Rifai N, et al. Glycosylated hemoglobin and risk of colorectal cancer and adenoma (United States). Cancer Causes Control 1999;10:379–386.
21. Wei EK, Ma J, Pollak MN, et al. C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev 2006;15:750–755."
So to avoid colorectal cancer, eat the diet that best controls your glycosylated hemoglobin. Anybody have Hemoglobin A1c (HbA1c) results to share, before and after your low-carb adventure?